Neuroendocrine differentiation in the progression of prostate cancer
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چکیده
منابع مشابه
Neuroendocrine differentiation in the progression of prostate cancer.
Neuroendocrine (NE) cells originally exist in the normal prostate acini and duct, regulating prostatic growth, differentiation and secretion. Clusters of malignant NE cells are found in most prostate cancer (PCa) cases. NE differentiation (NED) is the basic character of the prostate, either benign or malignant. NE cells hold certain peptide hormones or pro-hormones, which affect the target cell...
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In normal prostate, neuroendocrine (NE) cells are rare and interspersed among the epithelium. These cells are believed to provide trophic signals to epithelial cell populations through the secretion of an abundance of neuropeptides that can diffuse to influence surrounding cells. In the setting of prostate cancer (PC), NE cells can also stimulate surrounding prostate adenocarcinoma cell growth,...
متن کاملNeuroendocrine differentiation in prostate cancer.
As any organ in the body human prostate is composed of many different types of cells as well as extracellular components. During prostate development, reciprocal cellular interactions between stromal cells and prostate epithelial cells ultimately lead to the development of a mature prostate. Normal prostate is composed of repeating cellular units that contain stromal and epithelial compartments...
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Global Objectives: Review recent advances in the identification and diagnosis of current and emerging disease states. Discuss the pathophysiology of various disease states and the multidisciplinary considerations that affect patient care outcomes. Identify recent changes in requirements for accreditation, licensing, and regulatory compliance in across all divisions of pathology. Discuss...
متن کاملNeuroendocrine differentiation of prostate cancer: a review.
Neuroendocrine cells are one of the epithelial populations in the prostate. Neuroendocrine differentiation (NED) has been observed in prostate cancer. In addition to small cell neuroendocrine carcinomas and carcinoid tumors of the prostate, prostatic adenocarcinomas may have NED. The incidence and clinical relevance of NED in prostatic adenocarcinoma is not clearly understood because of conflic...
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ژورنال
عنوان ژورنال: International Journal of Urology
سال: 2008
ISSN: 0919-8172
DOI: 10.1111/j.1442-2042.2008.02175.x